Single Dose Metrifonate Or Praziquantel Treatment In Kenyan Children. Ii. Effects On Growth In Relation To Schistosoma Haematobium And Hookworm Egg Counts.
Date
1989-10Author
Stephenson, L S
Latham, M C
Kioti, S N
SKurz, K M
Type
ArticleLanguage
enMetadata
Show full item recordAbstract
We studied the growth of comparable groups of children with light to moderate Schistosoma haematobium infections who received a single dose of metrifonate (MT, 10 mg/kg), praziquantel (PR, 40 mg/kg), or a placebo (PL). Children were re-examined 8 months later. The MT and PR groups gained significantly more than the placebo group in weight, percent weight for age, percent weight for height, arm circumference, and in triceps and subscapular skinfold thicknesses. The MT and PR groups did not differ significantly from each other. The placebo group showed statistically significant decreases or no change between exams in percent weight for age, percent weight for height, percent arm circumference, and both skinfold thicknesses; the MT and PR groups exhibited highly significant increases in these parameters (P less than 0.0002). The intensity of S. haematobium infection had decreased significantly in both the MT and PR groups, but especially in the PR group. Multiple regression analyses showed that a decrease in the intensity of S. haematobium infection was by far the most important predictor of growth rate after treatment for all 5 anthropometric measures tested; decreases in the intensity of hookworm infection was also significant for 2 of the 5 measures.
URI
www.ncbi.nlm.nih.gov/whalecom0/pubmed/2508502http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/32110
Citation
Am J Trop Med Hyg. 1989 Oct;41(4):445-53Publisher
University of Nairobi Division of Nutritional Sciences, Cornell University, Ithaca, New York.
Collections
- Faculty of Health Sciences (FHS) [10378]