Plasma viral loads during early HIV-1 infection are similar in subtype C- and non-subtype C-infected African seroconverters.
Date
2013Author
Campbell, MS,
Kahle, EM
Celum, C
Lingappa, JR
Kapiga, S
Mujugira, A
Mugo, NR
Fife, KH
Mullins, JI
Baeten, JM
Type
ArticleLanguage
enMetadata
Show full item recordAbstract
Recent data suggest that infection with human immunodeficiency virus type 1 (HIV-1) subtype C results in prolonged high-level viremia (>5 log10 copies/mL) during early infection. We examined the relationship between HIV-1 subtype and plasma viremia among 153 African seroconverters. Mean setpoint viral loads were similar for C and non-C subtypes: 4.36 vs 4.42 log10 copies/mL (P = .61). The proportion of subtype C-infected participants with viral loads >5 log10 copies/mL was not greater than the proportion for those with non-C infection. Our data do not support the hypothesis that higher early viral load accounts for the rapid spread of HIV-1 subtype C in southern Africa.
URI
http://www.ncbi.nlm.nih.gov/pubmed/23315322http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/32180
Citation
Plasma viral loads during early HIV-1 infection are similar in subtype C- and non-subtype C-infected African seroconverters. Campbell MS, Kahle EM, Celum C, Lingappa JR, Kapiga S, Mujugira A, Mugo NR, Fife KH, Mullins JI, Baeten JM; J Infect Dis. 2013 Apr;207(7):1166-70. doi: 10.1093/infdis/jit015. Epub 2013 Jan 11.Publisher
Medicine, University of Washington, Seattle, WA 98195, USA