Trypan blue staining to determine vaginal exposure in two types of plastic vaginal applicators containing two different microbicide formulations

dc.contributor.author	Hemmerling, A
dc.contributor.author	Harrison, WG
dc.contributor.author	Brown, JM
dc.contributor.author	Moscicki, B
dc.contributor.author	Oziemkowska, M
dc.contributor.author	Bukusi, EA
dc.contributor.author	Cohen, CR
dc.date.accessioned	2013-06-12T12:31:44Z
dc.date.available	2013-06-12T12:31:44Z
dc.date.issued	2012
dc.identifier.citation	Sex Transm Dis. 2012 Sep;39(9):710-2.	en
dc.identifier.uri	http://www.ncbi.nlm.nih.gov/pubmed/22902667
dc.identifier.uri	http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/32310
dc.description.abstract	Dye staining of applicators has been shown to be a reliable and objective method to test vaginal insertion in clinical microbicide trials, but different plastics, dyes, and product formulations may impact the accuracy of this method. Reportedly used applicators returned from 3 clinical trials were stained with 1% trypan blue. In a phase 1 study (VivaGel), using gel-filled HTI polypropylene applicators, 1271 (97%) of applicators stained positive. In a phase 1 and a phase 2a study (LACTIN-V) using linear low-density polyethylene applicators to deliver a dry powder formulation, 57 (95%) and 135 (86%) tested positive, respectively. Dye staining of vaginal applicators is an objective low-cost measure suitable for low-resource settings.	en
dc.language.iso	en	en
dc.title	Trypan blue staining to determine vaginal exposure in two types of plastic vaginal applicators containing two different microbicide formulations	en
dc.type	Article	en