dc.contributor.author | Muok, EM | |
dc.contributor.author | Simiyu, EW | |
dc.contributor.author | Ochola, EA | |
dc.contributor.author | Ng'ang'a, ZW | |
dc.contributor.author | Secor, WE | |
dc.contributor.author | Karanja, DM | |
dc.contributor.author | Mwinzi, PM | |
dc.date.accessioned | 2013-06-13T06:16:12Z | |
dc.date.available | 2013-06-13T06:16:12Z | |
dc.date.issued | 2013-05 | |
dc.identifier.citation | Am J Trop Med Hyg. 2013 May 13. [Epub ahead of print] | en |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/pubmed/23669231 | |
dc.identifier.uri | http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/32613 | |
dc.description.abstract | Previously, we have shown that persons with human immunodeficiency virus 1 (HIV-1) infection and reduced CD4+ T-lymphocyte counts excrete significantly fewer Schistosoma mansoni eggs than HIV-1-negative persons with similar intensities of schistosome infections. To determine how antiretroviral therapy (ART) might affect egg excretion, we conducted a study of HIV+ adults living in an area highly endemic for S. mansoni as they began an ART program. Fecal egg excretion and CD4+ T-lymphocyte counts were evaluated at enrollment as well as 2 and 4 weeks after initiation of ART. Fourteen individuals who were Kato-Katz-negative at enrollment subsequently started excreting S. mansoni eggs accompanied by a significant increase in CD4+ T lymphocytes (P = 0.004). Study participants who were S. mansoni egg-positive at enrollment and received both praziquantel and ART also showed significantly increased CD4+ T-lymphocyte counts compared with baseline (P < 0.0001). Our data support a role for CD4+ T lymphocytes in S. mansoni egg excretion. | en |
dc.language.iso | en | en |
dc.publisher | University of Nairobi. | en |
dc.title | Association Between CD4+ T-Lymphocyte Counts and Fecal Excretion of Schistosoma mansoni Eggs in Patients Coinfected with S. mansoni and Human Immunodeficiency Virus Before and After Initiation of Antiretroviral Therapy. | en |
dc.type | Article | en |
local.publisher | College of Health Sciences | en |