dc.contributor.author | Irungu, E | |
dc.contributor.author | Mugo, N | |
dc.contributor.author | Ngure, K | |
dc.contributor.author | Njuguna, R | |
dc.contributor.author | Celum, C | |
dc.contributor.author | Farquhar, C | |
dc.contributor.author | Dhanireddy, S | |
dc.contributor.author | Baeten, JM | |
dc.date.accessioned | 2013-06-13T06:45:36Z | |
dc.date.available | 2013-06-13T06:45:36Z | |
dc.date.issued | 2013 | |
dc.identifier.citation | Immune response to hepatitis B virus vaccination among HIV-1 infected and uninfected adults in Kenya. Irungu E, Mugo N, Ngure K, Njuguna R, Celum C, Farquhar C, Dhanireddy S, Baeten JM. J Infect Dis. 2013 Feb 1;207(3):402-10. doi: 10.1093/infdis/jis695. Epub 2012 Nov 21 | en |
dc.identifier.uri | www.ncbi.nlm.nih.gov/whalecom0/pubmed/23175769 | |
dc.identifier.uri | http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/32657 | |
dc.identifier.uri | http://jid.oxfordjournals.org/content/207/3/402.long | |
dc.description.abstract | In studies from high-income countries, human immunodeficiency virus type 1 (HIV-1)-infected persons have diminished responses to hepatitis B virus (HBV) vaccination, compared with HIV-1-uninfected persons, but data from other settings are limited.
METHODS:
We compared the immune response to HBV vaccination among HIV-1-infected and HIV-1-uninfected Kenyan adults and assessed the response of HIV-1-infected initial nonresponders to revaccination with a standard HBV vaccine series.
RESULTS:
Of 603 participants, 310 (51.4%) were HIV-1-infected, for whom the median CD4(+) T-cell count was 557 cells/μL (interquartile range, 428-725 cells/μL); none were receiving antiretroviral therapy. Nonresponse to HBV vaccine was higher among HIV-1-infected participants, compared with HIV-1-uninfected participants (35.8% vs 14.3%; odds ratio, 3.33; P < .001). Of 102 HIV-1-infected initial nonresponders, 88 (86.3%) responded to revaccination, for an overall response, including to revaccination, of 94.9%. Among HIV-1-infected individuals, lower CD4(+) T-cell counts and male sex were independent predictors of nonresponse to initial vaccination, and lower body mass index, higher plasma HIV-1 RNA levels, and longer time to revaccination predicted nonresponse to revaccination.
CONCLUSIONS:
Kenyan adults had similar HBV vaccination responses as persons from high-income countries. Timely revaccination of HIV-1-infected nonresponders increased response to the vaccine to 95%. | en |
dc.language.iso | en | en |
dc.title | Immune response to hepatitis B virus vaccination among HIV-1 infected and uninfected adults in Kenya. | en |
dc.type | Article | en |
local.publisher | Epidemiology, University of Washington, Seattle, WA 98104, USA. | en |