dc.contributor.author | De Vuyst, H | |
dc.contributor.author | Mugo, NR | |
dc.contributor.author | Chung, MH | |
dc.contributor.author | McKenzie, KP | |
dc.contributor.author | Nyongesa-Malava, E | |
dc.contributor.author | Tenet, V | |
dc.contributor.author | Njoroge, JW | |
dc.contributor.author | Sakr, SR | |
dc.contributor.author | Meijer, CM | |
dc.contributor.author | Snijders, PJ | |
dc.contributor.author | Rana, FS | |
dc.contributor.author | Franceschi, S | |
dc.date.accessioned | 2013-06-13T06:50:09Z | |
dc.date.available | 2013-06-13T06:50:09Z | |
dc.date.issued | 2012 | |
dc.identifier.citation | Prevalence and determinants of human papillomavirus infection and cervical lesions in HIV-positive women in Kenya. De Vuyst H, Mugo NR, Chung MH, McKenzie KP, Nyongesa-Malava E, Tenet V, Njoroge JW, Sakr SR, Meijer CM, Snijders PJ, Rana FS, Franceschi S. Br J Cancer. 2012 Oct 23;107(9):1624-30. doi: 10.1038/bjc.2012.441. Epub 2012 Oct 2. | en |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/pubmed/23033006 | |
dc.identifier.uri | http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/32667 | |
dc.description.abstract | We assessed the association of human papillomavirus (HPV) infection and cervical intraepithelial neoplasia (CIN) with various characteristics, CD4 count and use of combination antiretroviral therapy (cART) among HIV-positive women.
METHODS:
Cross-sectional study of 498 HIV-positive women who underwent HPV PCR-based testing, cytology, and systematic cervical biopsy.
RESULTS:
In all, 68.7% of women were HPV-positive, 52.6% had high-risk (hr) HPV, and 40.2% multiple type infections. High-risk human papillomavirus-positivity did not vary significantly by age but it was negatively associated with education level. The most frequent types in 113 CIN2/3 were HPV16 (26.5%), HPV35 (19.5%), and HPV58 (12.4%). CD4 count was negatively associated with prevalence of hrHPV (P<0.001) and CIN2/3 among non-users of cART (P=0.013). Combination antiretroviral therapies users (≥2 year) had lower hrHPV prevalence (prevalence ratio (PR) vs non-users=0.77, 95% confidence interval (CI): 0.61-0.96) and multiple infections (PR=0.68, 95% CI: 0.53-0.88), but not fewer CIN2/3. The positive predictive value of hrHPV-positivity for CIN2/3 increased from 28.9% at age <35 years to 53.3% in ≥45 years.
CONCLUSION:
The burden of hrHPV and CIN2/3 was high and it was related to immunosuppression level. Combination antiretroviral therapies ( ≥2 year) use had a favourable effect on hrHPV prevalence but cART in our population may have been started too late to prevent CIN2/3. | en |
dc.language.iso | en | en |
dc.title | Prevalence and determinants of human papillomavirus infection and cervical lesions in HIV-positive women in Kenya. | en |
dc.type | Article | en |
local.publisher | International Agency for Research on Cancer, 150 Cours Albert Thomas, 69372 Lyon Cedex 08, Lyon, France. | en |