dc.contributor.author | Chung, MH | |
dc.contributor.author | McKenzie, KP | |
dc.contributor.author | Richardson, BA | |
dc.contributor.author | John-Stewart, GC | |
dc.contributor.author | Coombs, RW | |
dc.contributor.author | De Vuyst, H | |
dc.contributor.author | Njoroge, JW | |
dc.contributor.author | Nyongesa-Malava, E | |
dc.contributor.author | Sakr, SR | |
dc.contributor.author | Mugo, NR | |
dc.date.accessioned | 2013-06-13T07:31:01Z | |
dc.date.available | 2013-06-13T07:31:01Z | |
dc.date.issued | 2011 | |
dc.identifier.citation | Cervical HIV-1 RNA shedding after cryotherapy among HIV-positive women with cervical intraepithelial neoplasia stage 2 or 3. Chung MH, McKenzie KP, Richardson BA, John-Stewart GC, Coombs RW, De Vuyst H, Njoroge JW, Nyongesa-Malava E, Sakr SR, Mugo NR. AIDS. 2011 Sep 24;25(15):1915-9. doi: 10.1097/QAD.0b013e32834a3654 | en |
dc.identifier.uri | www.ncbi.nlm.nih.gov/whalecom0/pubmed/21716072 | |
dc.identifier.uri | http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/32745 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3248579/ | |
dc.description.abstract | OBJECTIVE:
To determine the effect of cryotherapy on HIV-1 cervical shedding.
DESIGN:
Prospective cohort study.
METHODS:
Five hundred HIV-positive women enrolled at an HIV treatment clinic in Nairobi, Kenya were screened for cervical cancer. Women diagnosed with cervical intraepithelial neoplasia stage 2 or 3 (CIN 2/3) by histology were offered cryotherapy treatment. The first 50 women had cervical swabs taken at baseline and at 2 and 4 weeks following treatment. Swabs were analyzed for HIV-1 RNA and compared using General Estimating Equation (GEE) with binomial or Gaussian links.
RESULTS:
Of the 50 women enrolled, 40 were receiving antiretroviral therapy (ART) and 10 were not receiving ART at the time of cryotherapy and during study follow-up. Among all women, the odds of detectable cervical HIV-1 RNA did not increase at 2 weeks [odds ratio (OR) 1.18; 95% confidence interval (CI) 0.65-2.13] or 4 weeks (OR 1.29; 95% CI 0.71-2.33) following cryotherapy. Among 10 women not receiving ART, the OR of detectable shedding at 2 weeks was higher, but not statistically significant (OR 4.02; 95% CI 0.53-30.79; P = 0.2), and at 4 weeks remained unchanged (OR 1.00; 95% CI 0.27-3.74).
CONCLUSION:
There was no increase in detectable cervical HIV-1 RNA among HIV-positive women after cryotherapy. The risk of HIV-1 transmission after cryotherapy may not be significant, particularly among women already on ART at the time of cervical treatment. However, further investigation is needed among women not receiving ART. | en |
dc.language.iso | en | en |
dc.title | Cervical HIV-1 RNA shedding after cryotherapy among HIV-positive women with cervical intraepithelial neoplasia stage 2 or 3. | en |
dc.type | Article | en |
local.publisher | Global Health, University of Washington, Seattle, USA | en |