In Vitro Production of Testosterone and Plasma Levels of Luteinising Hormone, Testosterone and Cortisol in Male Rats Treated with Heptachlor
Date
1997Author
Mugweru, J
Okindo, E
Odongo, H
Onyango, D.W
Wango, E.O
Type
ArticleLanguage
enMetadata
Show full item recordAbstract
Male rats were divided into six groups of five rats each. Rats were injected subcutaneously with different concentrations of heptachlor for 2 weeks. Heptachlor at all doses significantly suppressed plasma testosterone levels (P < 0.05). Plasma luteinizing hormone (LH) (P < 0.01) and cortisol (P < 0.02) levels were significantly elevated in heptachlor-treated rats as compared to corn oil–treated controls. LH and testosterone levels showed strong correlation (r = 0.69, P < 0.05). The testes in rats treated with 25 mg/kg body weight of heptachlor showed some pathological changes. We conclude that heptachlor causes adverse effects on several male reproductive parameters in rats.
URI
http://www.sciencedirect.com/science/article/pii/S0742841397001047http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/34054
Citation
Comparative Biochemistry and Physiology Part C: Pharmacology, Toxicology and Endocrinology Volume 118, Issue 3, November 1997, Pages 381–386Publisher
Elsevier, Reproductive Biology Unit, University of Nairobi, Nairobi, Kenya