Antiplasmodial and larvicidal flavonoids from Derris trifoliata
Kabaru, Jacques M
Akala, Hoseah M
Kiremire, Bernard T
Peter, Martin G
Eyase, Fredrick L
Waters, Norman C
Walsh, Douglas S
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From the dichloromethane-methanol (1:1) extract of the seed pods of Derris trifoliata, a new flavanone derivative (S)-lupinifolin 4´-methyl ether was isolated. In addition, the known flavonoids lupinifolin and rotenone were identified. The structures were determined on the basis of spectroscopic evidence. Lupinfolin showed moderate in vitro antiplasmodial activity against the D6 (chloroquine-sensitive) and W2 (chloroquineresistant) strains of Plasmodium falciparum. The different parts of this plant showed larvicidal activities against Aedes aegypti and rotenoids were identified as the active principles.
CitationBull. Chem. Soc. Ethiop. 2009, 23(3), 409-414.
Department of Chemistry, University of Nairobi,School of Biological Sciences, University of NairobiUnited States Army Medical Research Unit-Kenya, MRU 64109, APO, AE 09831-4109, USADepartment of Chemistry, Makerere University, P.O. Box 7062, Kampala, UgandaInstitut für Chemie, Universität Potsdam, P.O. Box 60 15 53, D-14415 Potsdam, Germany
(S)-Lupinifolin 4´-methyl ether