dc.contributor.author | Yenesew Abiy. | |
dc.contributor.author | Derese Solomon. | |
dc.contributor.author | Midiwo Jacob O. | |
dc.contributor.author | Oketch-Rabah Hellen A. | |
dc.contributor.author | Lisgartena John. | |
dc.contributor.author | Palmerc Rex. | |
dc.contributor.author | Heydenreich Matthias. | |
dc.contributor.author | Peter Martin G. | |
dc.contributor.author | Akala Hose. | |
dc.contributor.author | Wangui Julia. | |
dc.contributor.author | Liyala Pamela. | |
dc.contributor.author | Waters Norman C. | |
dc.date.accessioned | 2013-06-17T12:33:12Z | |
dc.date.available | 2013-06-17T12:33:12Z | |
dc.date.issued | 2003-10 | |
dc.identifier.citation | Phytochemistry Volume 64, Issue 3, October 2003, Pages 773–779 | en |
dc.identifier.uri | http://www.sciencedirect.com/science/article/pii/S003194220300373X | |
dc.identifier.uri | http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/34938 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/pubmed/13679101 | |
dc.description.abstract | The dichloromethane extract of the stem bark of Millettia usaramensis subspecies usaramensis showed anti-plasmodial activity against the chloroquine sensitive (D6) and chloroquine resistant (W2) strains of Plasmodium falciparum. Chromatographic separation of the extract led to the identification of a new rotenoid, (6aR,12aS)-2,3-methylenedioxy-9-methoxy-8-(3,3-dimethylallyl)-12a-hydroxyrotenoid (trivial name, usararotenoid C) along with known flavonoids (usararotenoid A, 12a-epimillettosin, 6a,12a-dehydromillettone, barbigerone and 4′-O-geranylisoliquiritigenin) as the anti-plasmodial principles. The structures were determined by spectroscopic analyses. CD and X-ray analyses established absolute configurations.
A new anti-plasmodial rotenoid, 1, along with known flavonoids were isolated from the stem bark of Millettia usaramensis subspecies usaramensis. The structures were determined on the basis of spectroscopic evidence. CD and X-ray analysis established absolute configurations. | en |
dc.language.iso | en | en |
dc.publisher | University of Nairobi | en |
dc.subject | Millettia usaramensis subspecies usaramensis;Leguminosae;Stem bark;Rotenoids;Usararotenoid A;12-Dihydrousararotenoid A;Usararotenoid C;NMR;CD;X-ray;Anti-plasmodial;Malaria;Plasmodium falciparum | en |
dc.title | Anti-plasmodial activities and X-ray crystal structures of rotenoids from Millettia usaramensis subspecies usaramensis | en |
dc.type | Article | en |
local.publisher | Department of Chemistry, University of Nairobi | en |
local.publisher | Department of Pharmacology and Pharmacognosy, University of Nairobi | en |
local.publisher | Department of Crystallography, Birkbeck College, University of London | en |