Potent Antimalarial Activity of the Alkaloid Nitidine, Isolated from a Kenyan Herbal Remedy
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Date
1995Author
GAKUNJU, DMN
MBERU, EK
DOSSAJI, SF
GRAY, AI
WAIGH, RD
WATERMAN, PG
WATKINS, WM
Type
ArticleLanguage
enMetadata
Show full item recordAbstract
Bioassay-guided fractionation of extracts of Toddalia asiatica, a plant used by the Pokot tribe of Kenya to
treat fevers, has yielded the alkaloid nitidine as the major antimalarial component. Fractions containing
nitidine have in vitro 50% inhibitory concentrations against Plasmodium falciparum in the range of 9 to 108
ng/ml for a range of chloroquine-susceptible and -resistant strains. The results show a lack of cross-resistance
between chloroquine and nitidine.
URI
http://www.ncbi.nlm.nih.gov/pubmed/8592987http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/34981
Citation
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, Dec. 1995, p. 2606–2609Publisher
Ministry of Health, Kenya The Wellcome Trust Research Laboratories The National Museums of Kenya, Kenya Medical Research Institute Department of Pharmaceutical Sciences, University of Strathclyde Department of Pharmacology and Therapeutics, University of Liverpool