Potent Antimalarial Activity of the Alkaloid Nitidine, Isolated from a Kenyan Herbal Remedy

dc.contributor.author	GAKUNJU, DMN
dc.contributor.author	MBERU, EK
dc.contributor.author	DOSSAJI, SF
dc.contributor.author	GRAY, AI
dc.contributor.author	WAIGH, RD
dc.contributor.author	WATERMAN, PG
dc.contributor.author	WATKINS, WM
dc.date.accessioned	2013-06-17T13:01:28Z
dc.date.issued	1995
dc.identifier.citation	ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, Dec. 1995, p. 2606–2609	en
dc.identifier.uri	http://www.ncbi.nlm.nih.gov/pubmed/8592987
dc.identifier.uri	http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/34981
dc.description.abstract	Bioassay-guided fractionation of extracts of Toddalia asiatica, a plant used by the Pokot tribe of Kenya to treat fevers, has yielded the alkaloid nitidine as the major antimalarial component. Fractions containing nitidine have in vitro 50% inhibitory concentrations against Plasmodium falciparum in the range of 9 to 108 ng/ml for a range of chloroquine-susceptible and -resistant strains. The results show a lack of cross-resistance between chloroquine and nitidine.	en
dc.language.iso	en	en
dc.title	Potent Antimalarial Activity of the Alkaloid Nitidine, Isolated from a Kenyan Herbal Remedy	en
dc.type	Article	en
local.publisher	Ministry of Health, Kenya	en
local.publisher	The Wellcome Trust Research Laboratories	en
local.publisher	The National Museums of Kenya,	en
local.publisher	Kenya Medical Research Institute	en
local.publisher	Department of Pharmaceutical Sciences, University of Strathclyde	en
local.publisher	Department of Pharmacology and Therapeutics, University of Liverpool	en