dc.contributor.author | Engelbert, M | |
dc.contributor.author | Miño de Kaspar, H | |
dc.contributor.author | Thiel, M | |
dc.contributor.author | Grasbon, T | |
dc.contributor.author | Ta, CN | |
dc.contributor.author | Schulze-Schwering, M | |
dc.contributor.author | Klauss, V | |
dc.contributor.author | Kampik, A | |
dc.date.accessioned | 2013-06-18T11:26:06Z | |
dc.date.available | 2013-06-18T11:26:06Z | |
dc.date.issued | 2004 | |
dc.identifier.citation | Graefes Arch Clin Exp Ophthalmol. 2004 Apr;242(4):313-20. Epub 2004 Feb 24. | en |
dc.identifier.uri | http://hinari-gw.who.int/whalecomwww.ncbi.nlm.nih.gov/whalecom0/pubmed/14986007 | |
dc.identifier.uri | http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/35542 | |
dc.description.abstract | BACKGROUND:
Controversy still surrounds the intravenous (IV) treatment of endophthalmitis. The purpose of this study was to compare IV and intraocular (IO) treatment in experimental Staphylococcus aureus endophthalmitis: intravitreal injection of vancomycin and amikacin (VA/AN) in comparison with IV imipenem (IPM) and a combination of IV and IO (IV+IO) therapy.
METHODS:
The right eyes of 27 rabbits were injected with 25000 S. aureus. After 24 h, animals were either treated with IO VA/AN ( n=5; 1.0 mg/0.4 mg in 0.1 ml saline), or IV IPM ( n=9; 37 mg/kg body weight 3x daily), or IV+IO therapy ( n=7), or served as untreated controls ( n=6). Clinical appearance was evaluated daily and vitreous aspirates were obtained for bacterial culture 24 h and 6 days after therapy, when the eyes were enucleated for histopathologic examination.
RESULTS:
Eyes in the IO or IO+IV treatment group had a significantly better appearance clinically and histologically than did eyes in the IV or untreated control group. Eyes in the IO+IV group had a similar appearance to the IO-treated eyes. All aspirates from the IO and IO+IV groups were culture-negative 24 hours after therapy, whereas only five of nine in the IV-treated group were culture-negative. Aspirates from all treatment groups were culture-negative by day 6 after the initiation of therapy. Untreated control eyes were culture-positive at all times.
CONCLUSION:
IO therapy with VA/AN proved more effective in treating experimental S. aureus endophthalmitis than did IV therapy with IPM alone. IV+IO treatment was not superior to IO treatment alone. | en |
dc.language.iso | en | en |
dc.title | Intravitreal vancomycin and amikacin versus intravenous imipenem in the treatment of experimental Staphylococcus aureus endophthalmitis. | en |
dc.type | Article | en |
local.publisher | Department of Ophthalmology, Ludwig-Maximilians-Universität, Mathildenstrasse 8, 80336, Munich, Germany. | en |