dc.contributor.author | Engelbert, M | |
dc.contributor.author | Miño de Kaspar, H | |
dc.contributor.author | Mette, M | |
dc.contributor.author | Thiel, M | |
dc.contributor.author | Ta, CN | |
dc.contributor.author | Grasbon, T | |
dc.contributor.author | Schulze-Schwering, M | |
dc.contributor.author | Klauss, V | |
dc.contributor.author | Kampik, A | |
dc.date.accessioned | 2013-06-18T11:37:20Z | |
dc.date.available | 2013-06-18T11:37:20Z | |
dc.date.issued | 2003 | |
dc.identifier.citation | Graefes Arch Clin Exp Ophthalmol. 2003 Dec;241(12):1029-36. Epub 2003 Nov 14 | en |
dc.identifier.uri | http://hinari-gw.who.int/whalecomwww.ncbi.nlm.nih.gov/whalecom0/pubmed/14618340 | |
dc.identifier.uri | http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/35550 | |
dc.description.abstract | BACKGROUND:
To compare the efficacy of intravenous (IV) imipenem (IPM) and a combination of IV ceftazidime (CAZ) and amikacin (AN) in the treatment of Staphylococcus aureus endophthalmitis in a rabbit model.
METHODS:
Right eyes of 60 albino rabbits were injected with 1000 colony-forming units of S. aureus intravitreally. After 24 h, treatment with either IV IPM (37.5 mg/kg) every 8 h ( n=18) or IV CAZ (50 mg/kg) and AN (10 mg/kg) every 8 hours ( n=18) was begun and continued until the animals were killed at the indicated timepoints; 24 control animals received no treatment. The concentration of bacteria in the vitreous from six animals per group was determined microbiologically on days 2, 3, and 5 after infection, and histologic examination was performed on all eyes.
RESULTS:
The number of eyes with positive cultures on day 5 was lower in the group that received IV IPM (2/6) compared with the IV CAZ/AN group (4/6) and the control group (6/6). For the culture-positive eyes, the bacterial concentrations were significantly lower for the IV IPM group compared with the IV CAZ/AN group on days 2 and 5 ( P<0.05 and P<0.0065, respectively), but not on day 3 ( P <0.8. Bacterial counts in both treatment groups were significantly lower than in the control group ( P<0.005). Eyes in all groups, however, showed severe intraocular inflammation.
CONCLUSIONS:
IV IPM is more effective than is IV CAZ/AN in reducing the number of bacteria in an animal model of S.aureus endophthalmitis. | en |
dc.language.iso | en | en |
dc.title | Intravenous treatment of experimental Staphylococcus aureus endophthalmitis: imipenem versus the combination of ceftazidime and amikacin. | en |
dc.type | Article | en |
local.publisher | Department of Ophthalmology, Ludwig-Maximilians-Universität, Mathildenstrasse 8, 80336 Munich, Germany. | en |