dc.contributor.author | Miño De Kaspar, H | |
dc.contributor.author | Hoepfner, AS | |
dc.contributor.author | Engelbert, M | |
dc.contributor.author | Thiel, M | |
dc.contributor.author | Ta, CN | |
dc.contributor.author | Mette, M | |
dc.contributor.author | Schulze-Schwering, M | |
dc.contributor.author | Grasbon, T | |
dc.contributor.author | Sesma-Vea, B | |
dc.contributor.author | Casas, JM | |
dc.contributor.author | Iturralde-Goñi, R | |
dc.contributor.author | Klauss, V | |
dc.contributor.author | Kampik, A | |
dc.date.accessioned | 2013-06-18T12:25:01Z | |
dc.date.available | 2013-06-18T12:25:01Z | |
dc.date.issued | 2001 | |
dc.identifier.citation | Ophthalmology. 2001 Mar;108(3):470-8. | en |
dc.identifier.uri | http://hinari-gw.who.int/whalecomwww.ncbi.nlm.nih.gov/whalecom0/pubmed/11237900 | |
dc.identifier.uri | http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/35631 | |
dc.description.abstract | OBJECTIVE:
To study whether the clinical outcome of Staphylococcus epidermidis-induced endophthalmitis in rabbits is related to the antibiotic resistance pattern of the infecting strain.
DESIGN:
Experimental animal study.
PARTICIPANTS:
The right eyes of 36 New Zealand white albino rabbits were inoculated with strains of S. epidermidis that displayed various patterns of antibiotic resistance.
METHODS:
There were 12 rabbits in each of three study groups: fully antibiotic susceptible (FS), partially antibiotic resistant (PR), and multiresistant (MR). Five days after inoculation, the eyes were enucleated and prepared for histologic studies.
MAIN OUTCOME MEASURES:
Comparisons among the three groups were made based on electroretinographic (ERG) findings, histologic evaluation by a masked observer, and clinical examination.
RESULTS:
Electroretinographic findings on all rabbits were made by an unmasked observer. At 30 hours after inoculation, the ERG was diminished to 65% of normal for group FS, compared with a flat ERG waveform for groups PR (P < 0.05) and MR (P < 0.05). The ERG waveform was flat for all three groups at 72 hours after inoculation. Histologic evaluation by use of a histologic score revealed that the degree of inflammation and destruction of the retina was less for group FS (n = 10) compared with groups PR (n = 8) and MR (n = 8). Clinical examination revealed that there was a trend of less ocular inflammation for group FS compared with groups PR and MR.
CONCLUSIONS:
In a rabbit model of S. epidermidis-induced endophthalmitis, antibiotic-susceptible strains caused less inflammation and destruction of the infected retina than did antibiotic-resistant strains. | en |
dc.language.iso | en | en |
dc.title | Antibiotic resistance pattern and visual outcome in experimentally-induced Staphylococcus epidermidis endophthalmitis in a rabbit model. | en |
dc.type | Article | en |
local.publisher | Department of Ophthalmology, Ludwig-Maximilians-Universität, Munich, Germany. | en |