Serological evidence for long-term epstein–barr virus reactivation in children living in a holoendemic malaria region of Kenya†
Date
2009Author
Erwan, Piriou
Rhonda, Kimmel
Kiprotich, Chelimo
Middeldorp, Jaap M
Odada, Peter Sumba
Snyder, Robert Ploutz
Moormann, Ann M
Rochford, Rosemary
Type
ArticleLanguage
enMetadata
Show full item recordAbstract
To study the long term the effects of chronic exposure to P. falciparum malaria on Epstein–Barr virus (EBV) reactivation in children, EBV-specific antibody levels were measured in a cross-sectional survey of two groups of Kenyan children with divergent malaria exposure, varying in age from 1 to 14 years. A total of 169 children were analyzed within three age groups (1–4 years, 5–9 years and 10–14 years). Using a Luminex assay, elevated levels of IgG to EBV lytic and latent antigens were observed in children from the holoendemic malaria area; these remained elevated for each age group studied. In comparison, children from the sporadic malaria area had lower levels of EBV-specific IgG antibodies and these levels declined across age groups. These data suggest that chronic exposure to malaria may lead to long-term EBV reactivation. J. Med. Virol. 81:1088–1093, 2009. © 2009 Wiley-Liss, Inc.
URI
http://onlinelibrary.wiley.com/doi/10.1002/jmv.21485/abstract?deniedAccessCustomisedMessage=&userIsAuthenticated=falsehttp://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/35869
Citation
Volume 81, Issue 6, pages 1088–1093, June 2009Publisher
College of Physical and Biological Sciences