dc.contributor.author | Erwan, Piriou | |
dc.contributor.author | Rhonda, Kimmel | |
dc.contributor.author | Kiprotich, Chelimo | |
dc.contributor.author | Middeldorp, Jaap M | |
dc.contributor.author | Odada, Peter Sumba | |
dc.contributor.author | Snyder, Robert Ploutz | |
dc.contributor.author | Moormann, Ann M | |
dc.contributor.author | Rochford, Rosemary | |
dc.date.accessioned | 2013-06-18T15:20:17Z | |
dc.date.available | 2013-06-18T15:20:17Z | |
dc.date.issued | 2009 | |
dc.identifier.citation | Volume 81, Issue 6, pages 1088–1093, June 2009 | en |
dc.identifier.uri | http://onlinelibrary.wiley.com/doi/10.1002/jmv.21485/abstract?deniedAccessCustomisedMessage=&userIsAuthenticated=false | |
dc.identifier.uri | http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/35869 | |
dc.description.abstract | To study the long term the effects of chronic exposure to P. falciparum malaria on Epstein–Barr virus (EBV) reactivation in children, EBV-specific antibody levels were measured in a cross-sectional survey of two groups of Kenyan children with divergent malaria exposure, varying in age from 1 to 14 years. A total of 169 children were analyzed within three age groups (1–4 years, 5–9 years and 10–14 years). Using a Luminex assay, elevated levels of IgG to EBV lytic and latent antigens were observed in children from the holoendemic malaria area; these remained elevated for each age group studied. In comparison, children from the sporadic malaria area had lower levels of EBV-specific IgG antibodies and these levels declined across age groups. These data suggest that chronic exposure to malaria may lead to long-term EBV reactivation. J. Med. Virol. 81:1088–1093, 2009. © 2009 Wiley-Liss, Inc. | en |
dc.language.iso | en | en |
dc.title | Serological evidence for long-term epstein–barr virus reactivation in children living in a holoendemic malaria region of Kenya† | en |
dc.type | Article | en |
local.publisher | College of Physical and Biological Sciences | en |