Antileukemic compounds derived by chemical modification of macrocyclic trichothecenes. 2. Derivatives of roridins A and H and verrucarins A and J
Date
1984-02Author
Jarvis Bruce B.
Midiwo Jacob O.
Mazzola Eugene P.
Type
ArticleLanguage
enMetadata
Show full item recordAbstract
Various 8 beta-hydroxy, 16-hydroxy, and 9 beta,10 beta-epoxy derivatives of roridins A and H and verrucarins A and J have been prepared and tested in vivo against P388 mouse leukemia. The 9 beta,10 beta-epoxy derivatives and 16-hydroxy derivatives consistently exhibit very high activity. The 8 beta-hydroxy-9 beta,10 beta-epoxy and 16-hydroxy-9 beta,10 beta-epoxy derivatives of verrucarin A and roridin A exhibit extraordinary activity against P388. The 8 beta-hydroxy-9 beta,10 beta-epoxy and 16-hydroxy-9 beta,10 beta-epoxy derivatives of verrucarin A and roridin A exhibit extraordinary against P388.
URI
http://pubs.acs.org/doi/abs/10.1021/jm00368a025http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/36960
http://www.ncbi.nlm.nih.gov/pubmed/6694172
Citation
J. Med. Chem., 1984, 27 (2), pp 239–244Publisher
College of Physical and Biological Sciences