| dc.contributor.author | Jarvis Bruce B. | |
| dc.contributor.author | Midiwo Jacob O. | |
| dc.contributor.author | Mazzola Eugene P. | |
| dc.date.accessioned | 2013-06-20T14:42:20Z | |
| dc.date.available | 2013-06-20T14:42:20Z | |
| dc.date.issued | 1984-02 | |
| dc.identifier.citation | J. Med. Chem., 1984, 27 (2), pp 239–244 | en |
| dc.identifier.uri | http://pubs.acs.org/doi/abs/10.1021/jm00368a025 | |
| dc.identifier.uri | http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/36960 | |
| dc.identifier.uri | http://www.ncbi.nlm.nih.gov/pubmed/6694172 | |
| dc.description.abstract | Various 8 beta-hydroxy, 16-hydroxy, and 9 beta,10 beta-epoxy derivatives of roridins A and H and verrucarins A and J have been prepared and tested in vivo against P388 mouse leukemia. The 9 beta,10 beta-epoxy derivatives and 16-hydroxy derivatives consistently exhibit very high activity. The 8 beta-hydroxy-9 beta,10 beta-epoxy and 16-hydroxy-9 beta,10 beta-epoxy derivatives of verrucarin A and roridin A exhibit extraordinary activity against P388. The 8 beta-hydroxy-9 beta,10 beta-epoxy and 16-hydroxy-9 beta,10 beta-epoxy derivatives of verrucarin A and roridin A exhibit extraordinary against P388. | |
| dc.language.iso | en | en |
| dc.title | Antileukemic compounds derived by chemical modification of macrocyclic trichothecenes. 2. Derivatives of roridins A and H and verrucarins A and J | en |
| dc.type | Article | en |
| local.publisher | College of Physical and Biological Sciences | en |
