Sildenafil in management of persistent pulmonary hypertension of the newborn: report of two cases
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Date
2006Author
Simiyu, DE
Okello, C
Nyakundi, EG
Tawakal, AH
Type
ArticleLanguage
enMetadata
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Persistent pulmonary hypertension of the newborn (PPHN) was described in 1969 by Gersomy and co-workers as persistent foetal circulation. Supra - systemic pulmonary artery pressures result in right to left shunting of blood through the ductus arteriosus and/or foramen ovale. This results from failure of the normal adaptation to extra uterine life of the foetal heart/lung system. The incidence is estimated at about 0.1-0.2% of live born infants, majority being term or post term. There is no race or gender related predisposition. Management was always difficult before the advent of nitric oxide (and now sildenafil). We report two newborn infants born at The Mater Hospital with perinatal asphyxia resulting in persistent pulmonary hypertension that were successfully managed with sildenafil
URI
http://www.ajol.info/index.php/eamj/article/view/9442http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/38224
Citation
East Afr Med J. 2006 Jun;83(6):337-340Publisher
KMA Department of Pediatrics, University of Nairobi, Department Of Pharmaceutics And Pharmacy Practice.
Collections
- Faculty of Health Sciences (FHS) [10377]