Evaluation of Urinary Tubular Enzymes as Screening Markers of Renal Dysfunction in Patients Suffering from Diabetes Mellitus
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Date
2011Author
Wilfred, K. Gatua
Makumi, Joseph N
Njagi, Eliud M.
Kigondu, Christine S
Mcligeyo, Seth O.
. Waithaka, Stanley K
Type
ArticleLanguage
enMetadata
Show full item recordAbstract
To determine the relationship between sub clinical kidney injury caused by diabetes mellitus and the
levels of urinary
enzymes; N-acetyl-1&
-D-glucosaminidase, lactate dehydrogenase, alkaline phosphatase and
gamma glutamyl transferase in relation to urinary c
oncentration of microprotein, serum urea and creatinine.
The study subjects comprised 251 patients with Diabetes
Mellitus (cases), and 73 healthy individuals (control
group). The cases were further subdivided into thos
e with normoproteinuria, microproteinuria and kidney
failure. Glomerular function was studied by urinary leve
ls of protein (U.mp), serum urea and creatinine while
proximal tubular structural integrity was studied by
determining the activities of the enzymes U.ALP, U.NAG,
U .y
-GT, and U.LDH. Compared with healthy individuals
, diabetic patients with normoproteinuria excreted
significantly high levels of U.ALP, U.LDH, U.y
-GT, and U.NAG (p<0.05). Patients with kidney impairment
excreted high levels of the enzymes and urinary micr
oprotein compared to healthy individuals and diabetic
patients without kidney failure. Diabetes mellitus leads to
subclinical renal injury; that urinary excretion of
U.ALP, U.LDH, U.y
-GT, and U.NAG could be useful biomarkers
for proximal tubular injury. These results
suggest that site-specific urinary biochemical markers
provide valuable information about early renal proximal
tubular insult that ultimately may precede glomerul
ar permeability in subjects with diabetes mellitus
Citation
Wilfred. K. Gatua, Joseph N. Makumi, Eliud M. Njagi, Christine S. Kigondu, Seth O. Mcligeyo and 5 Stanley K. Waithaka,Evaluation of Urinary Tubular Enzymes as Screening Markers of Renal Dysfunction in Patients Suffering from Diabetes Mellitus ,Asian Journal of Medical Sciences 3(3): 84-90, 2011Publisher
University of Nairobi, College of Health Sciences,
Subject
Diabetes mellitusglomerular function
kidney fa ilure
tubular integrity
urinary tubular enzymes
Collections
- Faculty of Health Sciences (FHS) [10378]