dc.contributor.author | Jonnalagadda, SR | |
dc.contributor.author | Brown, E | |
dc.contributor.author | Lohman-Payne, B | |
dc.contributor.author | Wamalwa, D | |
dc.contributor.author | Farquhar, C | |
dc.contributor.author | Tapia, K | |
dc.contributor.author | Cranmer, LM | |
dc.contributor.author | John-Stewart, GC | |
dc.date.accessioned | 2013-06-24T13:47:18Z | |
dc.date.available | 2013-06-24T13:47:18Z | |
dc.date.issued | 2012 | |
dc.identifier.citation | Infect Dis Obstet Gynecol. 2012;2012:950650 | en |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/pubmed/22496602 | |
dc.identifier.uri | http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/39104 | |
dc.description.abstract | Background: We determined the consistency of positive interferon-gamma (IFN-γ) release assays (IGRAs) to detect latent TB infection (LTBI) over one-year postpartum in HIV-1-infected women. Methods: Women with positive IGRAs during pregnancy had four 3-monthly postpartum IGRAs. Postpartum change in magnitude of IFN-γ response was determined using linear mixed models. Results: Among 18 women with positive pregnancy IGRA, 15 (83%) had a subsequent positive IGRA; 9 (50%) were always positive, 3 (17%) were always negative, and 6 (33%) fluctuated between positive and negative IGRAs. Women with pregnancy IGRA IFN-γ>8 spot forming cells (SFCs)/well were more likely to have consistent postpartum IGRA response (odds ratio: 10.0; 95% confidence interval (CI): 0.9-117.0). Change in IFN-γ response over postpartum was 10.2 SFCs/well (95% CI: -1.5-21.8 SFCs/well).Conclusion: Pregnancy positive IGRAs were often maintained postpartum with increased consistency in women with higher baseline responses. There were modest increases in magnitude of IGRA responses postpartum | en |
dc.language.iso | en | en |
dc.publisher | University of Nairobi. | en |
dc.title | Consistency of Mycobacterium tuberculosis-specific interferon-gamma responses in HIV-1-infected women during pregnancy and postpartum. | en |
dc.type | Article | en |
local.publisher | Department of Paediatrics | en |