In vitro study of the effects of khat (Catha edulis Forsk) extract on isolated mouse interstitial cells.
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Date
2007-04Author
Nyongesa, AW
Patel, NB
Onyango, DW
Wango, EO
Odongo, HO
Type
ArticleLanguage
enMetadata
Show full item recordAbstract
Isolated mouse interstitial cells were incubated with different concentrations of khat (Catha edulis) extract (0.06 mg/ml, 0.6 mg/ml, 6 mg/ml, 30 mg/ml and 60 mg/ml) and cell viability as well as testosterone concentration measured at 30 min intervals over a 3h incubation period. High concentrations of khat extract (30 mg/ml and 60 mg/ml) significantly inhibited testosterone production while low concentrations (0.06 mg/ml, 0.6 mg/ml and 6 mg/ml) significantly stimulated (P<0.05) testosterone production by mouse interstitial cells. Similarly, at concentrations of 30 mg/ml and 60 mg/ml, there was a significant decrease in interstitial cell viability, whereas at 0.06 mg/ml, 0.6 mg/ml and 6 mg/ml there was no significant decrease. There was only a weak correlation (r=0.39) between testosterone production and viable interstitial cells. We postulate that khat extract at high concentrations may cause reproductive function impairment in the user but at low concentrations, may enhance testosterone production with accompanying effects on reproductive functions in male mice.
URI
http://hinari-gw.who.int/whalecomwww.ncbi.nlm.nih.gov/whalecom0/pubmed/17113255http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/39187
Citation
J Ethnopharmacol. 2007 Apr 4;110(3):401-5.Publisher
University of Nairobi. Department of Veterinary Anatomy
Collections
- Faculty of Health Sciences (FHS) [10377]