Effects of codeine, naproxen and dexamethasone on formalin-induced pain in the naked mole-rat.
Date
1993-01Author
Karim, F
Kanui, T I
Mbugua, S
Type
ArticleLanguage
enMetadata
Show full item recordAbstract
A dilute solution of formalin (20 microliters of 10% formalin) was injected subcutaneously in the dorsal right hind paw of the naked mole-rat. The injection of the dilute formalin produced two periods of pain behaviour, the early (0-5 minutes) and the late phase (25-60 minutes). These were quantified as the total time spent licking the injected paw. Codeine phosphate (10, 25 or 50 mg kg-1) significantly reduced pain behaviour in both the early and late phase. Codeine administration also induced aggressive, hyperactive behaviour and motor impairment that was naloxone (2 mg kg-1) reversible. Naproxen (200 mg kg-1) and dexamethasone phosphate (30 mg kg-1) significantly reduced licking activity in the late phase only.
URI
http://hinari-gw.who.int/whalecomwww.ncbi.nlm.nih.gov/whalecom0/pubmed/8453032http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/40491
Citation
Neuroreport. 1993 Jan;4(1):25-8.Publisher
University of Nairobi. Department of Animal Physiology