dc.contributor.author | Karim, F | |
dc.contributor.author | Kanui, T I | |
dc.contributor.author | Mbugua, S | |
dc.date.accessioned | 2013-06-26T12:14:20Z | |
dc.date.available | 2013-06-26T12:14:20Z | |
dc.date.issued | 1993-01 | |
dc.identifier.citation | Neuroreport. 1993 Jan;4(1):25-8. | en |
dc.identifier.uri | http://hinari-gw.who.int/whalecomwww.ncbi.nlm.nih.gov/whalecom0/pubmed/8453032 | |
dc.identifier.uri | http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/40491 | |
dc.description.abstract | A dilute solution of formalin (20 microliters of 10% formalin) was injected subcutaneously in the dorsal right hind paw of the naked mole-rat. The injection of the dilute formalin produced two periods of pain behaviour, the early (0-5 minutes) and the late phase (25-60 minutes). These were quantified as the total time spent licking the injected paw. Codeine phosphate (10, 25 or 50 mg kg-1) significantly reduced pain behaviour in both the early and late phase. Codeine administration also induced aggressive, hyperactive behaviour and motor impairment that was naloxone (2 mg kg-1) reversible. Naproxen (200 mg kg-1) and dexamethasone phosphate (30 mg kg-1) significantly reduced licking activity in the late phase only. | en |
dc.language.iso | en | en |
dc.publisher | University of Nairobi. | en |
dc.title | Effects of codeine, naproxen and dexamethasone on formalin-induced pain in the naked mole-rat. | en |
dc.type | Article | en |
local.publisher | Department of Animal Physiology | en |