| dc.contributor.author | Amugune, BK | |
| dc.contributor.author | Thoithi, GN | |
| dc.contributor.author | Kibwage, IO | |
| dc.date.accessioned | 2013-06-27T06:12:31Z | |
| dc.date.available | 2013-06-27T06:12:31Z | |
| dc.date.issued | 2005 | |
| dc.identifier.citation | The East and Central African Journal of Pharmaceutical Sciences Vol. 8 (3) 2005: pp 19-25 | en |
| dc.identifier.uri | http://www.ajol.info/index.php/ecajps/article/view/9732 | |
| dc.identifier.uri | http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/40779 | |
| dc.description.abstract | A liquid chromatographic method for the simultaneous assay of four anticonvulsant drugs, phenobarbitone, ethosuximide, phenytoin and carbamazepine on a polystyrene-divinyl benzene column is described. The method was developed by the systematic study of different types of co-polymer materials, type and concentration of organic modifiers, buffer pH and concentration and column temperature. A PLRP-S 100 Å 8 µm column maintained at 60 oC and a mobile phase consisting of acetonitrile-tert-butanol-phosphate buffer (pH 7.6, 0.2 M)-water (25:5:10:60, v/v) were used. The flow rate was 1 ml/min with ultraviolet detection at 220 nm. The method has been validated and used for the analysis of raw materials, finished products and dissolution studies of the drugs. | en |
| dc.language.iso | en | en |
| dc.publisher | University of Nairobi | en |
| dc.subject | Liquid chromatography, co-polymer column, phenobarbitone, ethosuximide, phenytoin, carbamazepine. | en |
| dc.title | Liquid chromatographic analysis of phenobarbitone, ethosuximide, phenytoin and carbamazepine on a polystyrene-divinyl benzene column | en |
| dc.type | Article | en |
| local.publisher | College of Health Sciences,University of Nairobi | en |
