HIV-1 Env-specific cytotoxic T-lymphocyte responses in exposed, uninfected Kenyan sex workers: a prospective analysis.
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Date
2004-10-21Author
Kaul, R
Rutherford, J
Rowland-Jones, SL
Kimani, J
Onyango, JI
Fowke, K
MacDonald, K
Bwayo, JJ
McMichael, AJ
Plummer, FA
Type
ArticleLanguage
enMetadata
Show full item recordAbstract
The prospective significance of HIV-specific cytotoxic T lymphocyte (CTL) responses in highly exposed, persistently seronegative populations is unknown. In 1996-1997 we screened for CTL responses against HIV clade B Env in 39 recently enrolled Kenyan female sex workers, and followed these women prospectively. Annual HIV incidence was 5.8%. CTL were independently associated with age and recent HIV-1 exposure,but were not prospectively associated with protection in a multivariable model that included HIV-1 exposure and duration of sex work.
URI
http://www.ncbi.nlm.nih.gov/pubmed/15577632http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/41791
Citation
AIDS. 2004 Oct 21;18(15):2087-9.Publisher
University of Nairobi Department of Medical Microbiology
Collections
- Faculty of Health Sciences (FHS) [10377]