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    Vaccination of the vervet monkey (Cercopithecus aethiops) against infection with Schistosoma mansoni.

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    Date
    1992
    Author
    Mumo, J M
    Kinoti ., G K
    Type
    Article
    Language
    en
    Metadata
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    Abstract
    Pilot experiments were carried out to assess the immunizing potential of radiation-attenuated cercariae of S. mansoni. Groups of 4 monkeys each were vaccinated 4-5 times at 3-5-week intervals using cercariae which had received 10, 20, 40 or 60 krad of gamma radiation. Animals were vaccinated with 1000 or 2000 cercariae per kilogram of body weight. Overall the difference in worm burdens between the vaccinated and unvaccinated groups was highly significant (P greater than 0.01). The highest level of protection achieved was 44.4%. This was in monkeys which were immunized five times with 2000, 20-krad cercariae at 3-4-week intervals. Protection levels of 33.3%, 36.6% and 37.0% were achieved in groups which had received, respectively, 1000 20-krad cercariae, 1000 10-krad cercariae, 2000 40-krad cercariae and 2000 60-krad cercariae. Vaccination reduced faecal egg counts markedly and intestinal tissue egg counts by 20-40%. Antischistosomular antibody was detectable in vitro 3 weeks after the first vaccination. Schistosomule kill rates of up to 60% were observed in vitro
    URI
    http://www.ncbi.nlm.nih.gov/pubmed/1514046
    http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/41930
    Citation
    Scand J Immunol Suppl. 1992;11:23-8.
    Publisher
     
     
    Department of Human Pathology,University of Nairobi
     
    Collections
    • College of Health Sciences (CHS) [9806]

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