dc.contributor.author | Koesters, SA | |
dc.contributor.author | Matu, L | |
dc.contributor.author | Kiama, P | |
dc.contributor.author | Anzala, O | |
dc.contributor.author | Embree, J | |
dc.contributor.author | Plummer, FA | |
dc.contributor.author | Kimani, J | |
dc.contributor.author | Fowke, KR. | |
dc.date.accessioned | 2013-06-28T14:39:06Z | |
dc.date.available | 2013-06-28T14:39:06Z | |
dc.date.issued | 2004-11 | |
dc.identifier.citation | J Clin Immunol. 2004 Nov;24(6):702-9. | en |
dc.identifier.uri | http://hinari-gw.who.int/whalecomwww.ncbi.nlm.nih.gov/whalecom0/pubmed/15622455 | |
dc.identifier.uri | http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/41939 | |
dc.description.abstract | The infectious burden leading to immune activation can vary between different populations and lead to various immune dysfunctions. We compared the effect of immune activation on apoptosis and T cell function in HIV uninfected individuals from Nairobi, Kenya (n=34), and Winnipeg, Canada (n=10). Women from Nairobi had a significantly greater number of CD8+ T cells expressing the activation markers CD38 and HLA DR. Kenyan women also had significantly higher levels of CTLA-4+ CD4 and CD8+ T cells, and reduced levels of CD28+ CD8+ cells. Levels of CD95+ CD4+ T cells were higher in Kenyan women and, correspondingly, showed higher levels of spontaneous apoptosis. Kenyan women also demonstrated hyper-responsiveness to T cell activation as assessed by interferon gamma production. This study demonstrates that in a population of Kenyan women with high levels of T cell activation, there were also elevated levels of T cell apoptotic death and hyper-responsiveness. These differences may influence the efficacy of immune responses to pathogens and must be considered when testing candidate vaccines. | en |
dc.language.iso | en | en |
dc.publisher | University of Nairobi | en |
dc.title | Elevation Of Immune Activation In Kenyan Women Is Associated With Alterations In Immune Function: Implications For Vaccine Development. | en |
dc.type | Article | en |
local.publisher | Department of Medical Microbiology | en |