dc.contributor.author | Iqbal, SM | |
dc.contributor.author | Ball, TB | |
dc.contributor.author | Kimani, J | |
dc.contributor.author | Kiama, P | |
dc.contributor.author | Thottingal, P | |
dc.contributor.author | Embree, JE | |
dc.contributor.author | Fowke, KR | |
dc.contributor.author | Plummer, FA. | |
dc.date.accessioned | 2013-06-28T14:47:13Z | |
dc.date.available | 2013-06-28T14:47:13Z | |
dc.date.issued | 2005-09 | |
dc.identifier.citation | J Infect Dis. 2005 Sep 1;192(5):728-38. Epub 2005 Jul 27. | en |
dc.identifier.uri | http://hinari-gw.who.int/whalecomwww.ncbi.nlm.nih.gov/whalecom0/pubmed | |
dc.identifier.uri | http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/41952 | |
dc.description.abstract | The initial site of exposure to human immunodeficiency virus (HIV)-1 during heterosexual transmission occurs in the genital tract. Although the majority of immunological studies have focused on the immune response to HIV-1 at the systemic level, our understanding of tissue-specific immunity is deficient. The goal of the present study was to characterize T cell populations found in the cervix of women shown to be resistant to infection by HIV-1. Levels of both systemic and cervical mucosal lymphocytes were compared between HIV-1-resistant, HIV-1-uninfected, and HIV-1-infected commercial sex workers (CSWs) as well as HIV-1-uninfected non-CSW control subjects at low risk for exposure. The HIV-1-resistant CSWs had increased cervical CD4+ and CD8+ T cell counts, compared with the HIV-1-uninfected CSWs; importantly, these increases were not reflected in the systemic lymphocyte compartment. There was a 2-fold increase in CD4+ T cell counts in the HIV-1-resistant CSWs, compared with both the HIV-1-infected and the HIV-1-uninfected CSWs. Expression of the HIV-1 coreceptors CCR5 and CXCR4 was also determined, and cytokine and beta chemokine levels in the genital mucosa were assessed. The HIV-1-resistant CSWs had a 10-fold increase in RANTES expression, compared with the HIV-1-uninfected CSWs. This is the first study to show elevated levels of beta chemokines and CD4+ T cells in the genital tracts of women who are exposed to HIV-1 and yet are uninfected. | en |
dc.language.iso | en | en |
dc.publisher | University of Nairobi | en |
dc.title | Elevated T Cell Counts And Rantes Expression In The Genital Mucosa Of Hiv-1-resistant Kenyan Commercial Sex Workers. | en |
dc.type | Article | en |
local.publisher | Department of Medical Microbiology | en |