Cd4+ T Cell Responses In Hiv-exposed Seronegative Women Are Qualitatively Distinct From Those In Hiv-infected Women
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Date
2005-01Author
Alimonti, JB
Koesters, SA
Kimani, J
Matu, L
Wachihi, C
Plummer, FA
Fowke, KR
Type
ArticleLanguage
enMetadata
Show full item recordAbstract
The immune response of human immunodeficiency virus (HIV)-exposed seronegative (ESN) women may be qualitatively different from that in those infected with HIV (HIV(+)). In a cohort of female commercial sex workers in Nairobi, Kenya, we found significantly lower (P< or =.01) levels of CD4(+)-specific immune activation and apoptosis in the ESN women compared with those in the HIV(+) women. Compared with the HIV(+) women, a lower proportion of the ESN women showed p24 peptide pool responses by the short-term, CD4(+)-specific, interferon (IFN)- gamma intracellular cytokine staining assay, whereas the proportion showing responses by the long-term, CD8(+)-depleted T cell proliferation assay was similar. Interestingly, the ESN responders had a 4.5-fold stronger proliferation response (P=.002) than the HIV(+) group. These data suggest that, compared with those in HIV(+) women, CD4(+) T cells in ESN women have a much greater ability to proliferate in response to p24 peptides.
URI
http://hinari-gw.who.int/whalecomwww.ncbi.nlm.nih.gov/whalecom0/pubmedhttp://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/41969
Citation
J Infect Dis. 2005 Jan 1;191(1):20-4. Epub 2004 Dec 1Publisher
University of Nairobi Department of Medical Microbiology
Collections
- Faculty of Health Sciences (FHS) [10387]