Identification of a novel HLA B*57 restricted cytotoxic T-lymphocyte epitope within HIV-1 rev
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HLA-B5701 and its related allele B5703 have been shown to be strongly associated with slow HIV-1 disease progression. To elucidate the effect of these alleles fully on disease progression it is essential to identify key HIV-1 epitopes that are restricted by these alleles. Here we describe the identification of a novel HLA-B5701, B5703 restricted epitope within HIV-1 rev, which accounted for up to 25 and 40% of the total cytotoxic T-lymphocyte responses in two patients
CitationMakadzange AT, Gillespie G, Kimani J, Kiama P, Easterbrook P, Bwayo JJ, Rowland-Jones S;Identification of a novel HLA B*57 restricted cytotoxic T-lymphocyte epitope within HIV-1 revL.
University of Nairobi,College of Health Sciences,