dc.contributor.author | Baeten, JM | |
dc.contributor.author | McClelland, RS | |
dc.contributor.author | Corey, L | |
dc.contributor.author | Overbaugh, J | |
dc.contributor.author | Lavreys, L | |
dc.contributor.author | Richardson, BA | |
dc.contributor.author | Wald, A | |
dc.contributor.author | Mandaliya, K | |
dc.contributor.author | Bwayo, JJ | |
dc.contributor.author | Kreiss, JK | |
dc.contributor.author | Ndinya-Achola Jeckoniah O. | |
dc.date.accessioned | 2013-06-29T09:22:01Z | |
dc.date.available | 2013-06-29T09:22:01Z | |
dc.date.issued | 2004 | |
dc.identifier.citation | Baeten JM, McClelland RS, Corey L, Overbaugh J, Lavreys L, Richardson BA, Wald A, Mandaliya K, Bwayo JJ, Kreiss JK;Vitamin A supplementation and genital shedding of herpes simplex virus among HIV-1-infected women: a randomized clinical trial.;J Infect Dis. 2004 Apr 15;189(8):1466-71. Epub 2004 Apr 2. | en |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/pubmed/15073684 | |
dc.identifier.uri | http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/42255 | |
dc.description.abstract | Cross-sectional analyses have associated vitamin A deficiency with genital shedding of herpes simplex virus (HSV) among human immunodeficiency virus type 1 (HIV-1)-infected women. A randomized clinical trial of vitamin A supplementation given daily for 6 weeks was conducted among 376 women in Mombasa, Kenya, who were coinfected with HSV-2 and HIV-1. At follow-up, there was no significant difference in the detection of genital HSV DNA between women receiving vitamin A supplementation and women receiving placebo (40% vs. 44%, respectively; P = .5) Among women shedding HSV, there was no significant difference in the mean HSV DNA quantity between the group that received vitamin A supplementation and the group that received placebo (4.51 vs. 4.67 log10 copies/swab; P = .6). HSV shedding was associated with significantly higher vaginal and cervical HIV-1 shedding, even after controlling for the plasma HIV-1 load and the CD4 count. Vitamin A supplementation is unlikely to decrease HSV shedding | en |
dc.language.iso | en | en |
dc.publisher | University of Nairobi, | en |
dc.title | Vitamin A supplementation and genital shedding of herpes simplex virus among HIV-1-infected women: a randomized clinical trial. | en |
dc.type | Article | en |
local.publisher | College of Health Sciences, | en |