Antinocieptive and anti-inflammatory effects of Toddalia asiatica (L) Lam. (Rutaceae) root extract in Swiss albino mice.
Date
2013-04Author
Kariuki, HN
Kanui, TI
Yenesew Abiy
Patel, N
Mbugua, PM
Type
ArticleLanguage
enMetadata
Show full item recordAbstract
INTRODUCTION:
Toddalia asiatica is a commonly used medicinal plant in East Africa for the management of pain and inflammatory conditions. The present study investigated the antinociceptive and the anti-inflammatory effects of T. asiatica in Swiss albino mice.
METHODS:
The antinociceptive and the anti-inflammatory effects of T. asiatica were investigated using formalin-induced pain test and the carrageenin-induced oedema paw. The extract solvent (vehicle), aspirin and indomethacin were employed as negative and positive controls respectively. Eight mice were used in each experiment.
RESULTS:
In the early phase of the formalin test, the 100mg/kg dose showed no significant antinociceptive activity while the 200mg/kg showed significant (p < 0.01) antinociceptive activity. The 100 mg/kg dose showed highly significant antinociceptive activity (p < 0.001) in the late phase of the formalin test while the 200mg/kg dose showed no significant antinociceptive activity. A reduction in carragenin induced acute inflammation paw oedema was significant (p < 0.01) following administration of 100mg/kg dose but not with the 200mg/kg dose.
CONCLUSION:
The present study therefore lends support to the anecdotal evidence for use of T. asiatica in the management of painful and inflammatory conditions.
URI
http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/44266http://www.ncbi.nlm.nih.gov/pubmed/23734278
Citation
Kariuki HN, Kanui TI, Yenesew A, Patel N, Mbugua PM.;Antinocieptive and anti-inflammatory effects of Toddalia asiatica (L) Lam. (Rutaceae) root extract in Swiss albino mice.;Pan Afr Med J. 2013 Apr 6;14:133.Publisher
University of Nairobi, College of Health Sciences,
Subject
Anti-inflammatoryAntinociceptive
Toddalia asiatica
carrageenin test
formalin test
mice
root extrac
Collections
- Faculty of Health Sciences (FHS) [10378]