High Prevalence Of Chlamydia Trachomatis And Neisseria Gonorrhoeae Infections Among Hiv-1 Negative Men Who Have Sex With Men In Coastal Kenya.
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Date
2010-11Author
Sanders, EJ
Thiong'o, AN
Okuku, HS
Mwambi, J
Priddy, F
Shafi, J
de Vries, H
McClelland, RS
Graham, S M.
Type
ArticleLanguage
enMetadata
Show full item recordAbstract
OBJECTIVES:
To assess the burden of Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (NG) in high-risk HIV-1 negative men who have sex with men (MSM) in Africa.
METHODS:
Before the start of a pre-exposure prophylaxis trial, HIV-1 negative volunteers were screened for sexually transmitted infection (STI) including CT and NG, using a highly sensitive and specific nucleic acid amplification test. Samples positive for CT by Aptima testing, were evaluated for the presence of lymphogranuloma venereum (LGV) serovars using an in-house PCR assay. All men were asked to submit a urine specimen, and all had a rectal swab collected by a clinician. Men were asked if they had dysuria, urethral or rectal discharge, or rectal pain.
RESULTS:
43 HIV-1 negative MSM were screened, of whom 13 reported sex with men only; the majority (27/43) reported sex work. One volunteer had dysuria and another, rectal pain. Eleven MSM (26%, 95% CI 14% to 41%) had infections with either or both pathogens. Homosexual men had a higher prevalence of any infection than bisexual men (46% vs 17%, p=0.04), and all cases of rectal infections, including one with CT, two with NG and two with CT/NG co-infection. All patients with CT were negative for LGV. One patient with a rectal NG infection reported rectal pain.
CONCLUSIONS:
A remarkably high burden of STI infection was found among HIV-1 negative MSM. Most (12/13) infections, including three of four rectal NG infections, were subclinical. These findings suggest that high-risk MSM will benefit from effective STI screening in Kenya.
URI
http://hinari-gw.who.int/whalecomwww.ncbi.nlm.nih.gov/whalecom0/pubmed/20656722http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/44380
Citation
ex Transm Infect. 2010 Nov;86(6):440-1. doi: 10.1136/sti.2010.043224. Epub 2010 Jul 23.Publisher
University of Nairobi Institute of Tropica and Infectious Diseases(UNITID)
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- Faculty of Health Sciences (FHS) [10378]