Anti-plasmodial flavonoids from the stem bark of Erythrina abyssinica
Date
2004Author
Yenesew Abiy.
Induli Martha.
Derese Solomon.
Midiwo Jacob O.
Heydenreich Matthias.
Peter Martin G
Akala Hoseah.
Wangui Julia.
Liyala Pamela.
Waters Norman C.
Type
ArticleLanguage
enMetadata
Show full item recordAbstract
The ethyl acetate extract of the stem bark of Erythrina abyssinica showed anti-plasmodial activity against the chloroquine-sensitive (D6) and chloroquine-resistant (W2) strains of Plasmodium falciparum with IC50 values of 7.9 ± 1.1 and 5.3 ± 0.7 μg/ml, respectively. From this extract, a new chalcone, 2′,3,4,4′-tetrahydroxy-5-prenylchalcone (trivial name 5-prenylbutein) and a new flavanone, 4′,7-dihydroxy-3′-methoxy-5′-prenylflavanone (trivial name, 5-deoxyabyssinin II) along with known flavonoids have been isolated as the anti-plasmodial principles. The structures were determined on the basis of spectroscopic evidence.
URI
http://www.sciencedirect.com/science/article/pii/S003194220400442Xhttp://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/44548
http://www.ncbi.nlm.nih.gov/pubmed/15504437
Citation
Abiy Yenesew, Martha Induli, Solomon Derese et al (2004). Anti-plasmodial flavonoids from the stem bark of Erythrina abyssinica. Phytochemistry Volume 65, Issue 22, November 2004, Pages 3029–3032Publisher
Department of Chemistry, University of Nairobi Institut für Chemie, Universität Potsdam, Germany United States Army Medical Research Unit-Kenya, USA