dc.contributor.author | Adem, A | |
dc.contributor.author | Asblom, A | |
dc.contributor.author | Johansson, G | |
dc.contributor.author | Mbugua, PM | |
dc.contributor.author | Karlsson, E | |
dc.date.accessioned | 2013-07-03T14:56:45Z | |
dc.date.available | 2013-07-03T14:56:45Z | |
dc.date.issued | 1988 | |
dc.identifier.citation | Biochim Biophys Acta. 1988 Mar 11;968(3):340-5. | en |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/pubmed/?term=Toxins+From+The+Venom+Of+The+Green+Mamba+Dendroaspis+Angusticeps+That+Inhibit+The+Binding+Of+Quinuclidinyl+Benzilate+To+Muscarinic+Acetylcholine+Receptors+%28BBA+12211%29. | |
dc.identifier.uri | http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/44867 | |
dc.description.abstract | Two protein toxins that displace the muscarinic antagonist quinuclidinyl benzilate from rat cortex synaptosomal membranes have been isolated from the green mamba (Dendroaspis angusticeps) venom by gel filtration on sephadex G-50, chromatography on the ion-exchangers Bio-Rex 70 and Sulphopropyl-Sephadex C-25 and reversed-phase HPLC. Toxin 1 has 64 amino acids and four disulfides and a formula weight of 7200 and the corresponding values for toxin 2 are 63, 4 and 6840, respectively. Ultracentrifugation gave a molecular weight of 6900 for toxin 1 and 6700 for toxin 2, Quinuclidinyl benzilate that binds to all types of muscarinic cholinergic receptor was displaced to about 50% by both toxins. This partial displacement indicates that the toxins might be specific for one subtype of receptor. | en |
dc.language.iso | en | en |
dc.publisher | University of Nairobi | en |
dc.title | Toxins From The Venom Of The Green Mamba Dendroaspis Angusticeps That Inhibit The Binding Of Quinuclidinyl Benzilate To Muscarinic Acetylcholine Receptors (BBA 12211). | en |
dc.type | Article | en |
local.publisher | Department of Medical Physiology | en |