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    Vaccination against hepatitis A virus may not be required for schoolchildren in northern India

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    Date
    2002
    Author
    Batra, Y
    Bhatkal, B
    Ojha, B
    Kaur, K
    Saraya, A
    Panda, SK
    Acharya, KS
    Type
    Article
    Language
    en
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    Abstract
    OBJECTIVES: To evaluate the current seroprevalence of antibodies against hepatitis A virus (HAV) in a sample of schoolchildren above 10 years of age and to determine the prevalence of HAV-induced hepatitis in adults at a tertiary care hospital in northern India between January 1992 and December 2000. METHODS: Sera from 276 male and 224 female schoolchildren aged 10-17 years were tested for anti-HAV antibodies by enzyme-linked immunosorbent assay. Consecutive patients with a diagnosis of acute viral hepatitis who attended a liver clinic were tested for the serological markers of HAV, hepatitis B Virus, hepatitis C virus, hepatitis D virus, and hepatitis E virus. FINDINGS: Of the male and female children, 96.3% and 98.2%, respectively had anti-HAV antibodies in their sera. The prevalence of these antibodies in the age groups 10-12, 13- 14, and 15-17 years were 98.6%, 94.8%, and 98.3% respectively. The frequency of HAV- induced acute viral hepatitis (69/870, 8%) in adults did not show an increasing trend. CONCLUSION: Mass HAV vaccination may be unnecessary in northern India because the seroprevalence of protective antibodies against HAV in schoolchildren aged over 10 years remains above 95% and there has been no apparent increase in HAV-induced acute viral hepatitis in adults.
    URI
    http://profiles.uonbi.ac.ke/sacharya/publications/batra-y-bhatkal-b-ojha-b-kaur-k-saraya-panda-sk-acharya-skvaccination-against-
    http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/45009
    Citation
    KIRTDA, DRACHARYAS. 2002. Batra Y, Bhatkal B, Ojha B, Kaur K, Saraya A, Panda SK, Acharya SK.Vaccination against hepatitis A virus may not be required for schoolchildren in northern India: results of a seroepidemiological survey.Bull World Health Organ. 2002;80(9):728-31
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