dc.contributor.author | Nyachieo, A | |
dc.contributor.author | Kiraithe, MM | |
dc.contributor.author | Spiessens, C | |
dc.contributor.author | Chai, DC | |
dc.contributor.author | Kiulia, NM | |
dc.contributor.author | D'hooghe, TM | |
dc.contributor.author | Mwenda JM | |
dc.date.accessioned | 2013-07-09T12:24:59Z | |
dc.date.available | 2013-07-09T12:24:59Z | |
dc.date.issued | 2013 | |
dc.identifier.citation | Nyachieo A, Kiraithe MM, Spiessens C, Chai DC, Kiulia NM, D'Hooghe TM, Mwenda JM. Short-term effects of high-dose khat on sperm parameters and reproductive hormonal levels in olive baboons (Papio anubis).. Vol. 75.; 2013. Gynecol. Obstet. Invest. 75(2). | en |
dc.identifier.uri | http://www.karger.com/Article/Abstract/345308 | |
dc.identifier.uri | http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/46746 | |
dc.description.abstract | The biological effects of khat (Catha edulis) on reproduction and fertility are inadequately investigated and controversial, hence we determined the effects of oral administration of high-dose khat on sperm parameters and male hormonal levels in olive baboons. In this study, 6 male baboons received a high dose of khat (500 g/week) during 1 month. Electroejaculation for sperm studies (concentration, motility and chromatin integrity) and plasma collection for hormonal analysis (testosterone, prolactin and cortisol) were done weekly during 1 month before and 1 month during khat administration as well as 2 weeks after the last dose of khat administration. Administration of khat extract induced a significant reduction in sperm motility (p = 0.008), sperm count (p = 0.041), sperm chromatin integrity (p = 0.0003), testosterone levels (p = 0.035) and prolactin levels (p = 0.0115), but not in cortisol levels and sperm volume (p > 0.05). The results suggest that high-dose khat decreases sperm quality and testosterone and hence may contribute to male infertility. | en |
dc.language.iso | en | en |
dc.publisher | University of Nairobi, | en |
dc.title | Short-term effects of high-dose khat on sperm parameters and reproductive hormonal levels in olive baboons (Papio anubis) | en |
dc.type | Article | en |
local.publisher | College of Health Sciences, | en |