Genital shedding of human immunodeficiency virus type 1 DNA during pregnancy: association with immunosuppression, abnormal cervical or vaginal discharge, and severe vitamin A deficiency.
Date
1997Author
John, G.C.
Nduati, R.W
Mbori-Ngach
Type
ArticleLanguage
enMetadata
Show full item recordAbstract
The presence of human immunodeficiency virus type 1 (HIV-1) in genital secretions may be a determinant of vertical HIV-1 transmission. Cervical and vaginal secretions from HIV-1-seropositive pregnant women were evaluated to determine prevalence and correlates of HIV-1-infected cells in the genital tract. HIV-1 DNA was detected by polymerase chain reaction in 32% of 212 cervical and 10% of 215 vaginal specimens. Presence of HIV-1 DNA in the cervix was associated with cervical mucopus and a significantly lower absolute CD4 cell count (354 vs. 469, P < .001). An absolute CD4 cell count <200 was associated with a 9.6-fold increased odds of cervical HIV-1 DNA detection compared with a count > or = 500 (95% confidence interval, 2.8-34.2). Detection of vaginal HIV- 1 DNA was associated with abnormal vaginal discharge, lower absolute CD4 cell count, and severe vitamin A deficiency. Presence of HIV-1-infected cells in genital secretions was associated with immunosuppression and abnormal cervical or vaginal discharge.
URI
http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/47121http://www.ncbi.nlm.nih.gov/pubmed/8985196
Citation
MBORI-, PROFNGACHADOROTHYA, W. PROFNDUATIRUTH. 1997. Genital shedding of human immunodeficiency virus type 1 DNA during pregnancy: association with immunosuppression, abnormal cervical or vaginal discharge, and severe vitamin A deficiency. J Infect Dis. 1997 Jan;175(1):57-62. John GC, Nduati RW, Mbori-Ngach. J Infect Dis. 1997 Jan;175(1):57-62.. : Earthscan, London. 978-1-84407-469-3Publisher
University of Nairobi
Collections
- Faculty of Health Sciences (FHS) [10377]