Human immunodeficiency virus type 1-infected cells in breast milk: association with immunosuppression and vitamin A deficiency.
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Date
1995Author
Nduati, R.W.
John GC, M. Richardson BA, Overbaugh J, Welch M,
Ndinya-Achola, J
Moses, S.
Holmes
Type
ArticleLanguage
enMetadata
Show full item recordAbstract
Breast milk samples from human immunodeficiency virus type 1 (HIV-1)-seropositive women were analyzed by polymerase chain reaction to determine the prevalence and determinants of HIV-1-infected cells in breast milk. Breast milk samples (212) were collected from 107 women, and 58% of the samples had detectable HIV-1 DNA. The proportion of HIV-1-infected cells in the milk samples ranged from 1 to 3255/10(4) cells. Breast milk samples with detectable HIV-1 DNA were more likely to be from women with absolute CD4 cell counts of < 400 (odds ratio, 3.1; 95% confidence interval [CI], 1.5-7.0). Severe vitamin A deficiency (< 20 micrograms/dL) was associated with a 20-fold increased risk of having HIV-1 DNA in breast milk among women with < 400 CD4 cells/mm3 (95% CI, 2.1-188.5). Women with CD4 cell depletion, especially those with vitamin A deficiency, may be at increased risk of transmitting HIV-1 to their infants through breast milk.
URI
http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/47391http://www.ncbi.nlm.nih.gov/pubmed/7594703
Citation
W., PROFNDUATIRUTH. 1995. Human immunodeficiency virus type 1-infected cells in breast milk: association with immunosuppression and vitamin A deficiency. J Infect Dis. 1995 Dec;172(6):1461-8. Nduati RW, John GC, Richardson BA, Overbaugh J, Welch M, Ndinya-Achola J, Moses S, Holmes. J Infect Dis. 1997 Jan;175(1):57-62.. : Journal of School of Continuous and Distance EducationPublisher
University of Nairobi
Collections
- Faculty of Health Sciences (FHS) [10387]