Quantitative Assessment Of Oestrogen And Progesterone Receptors On Fine-needle Aspirates And Cryostat Sections Of Breast Carcinomas: How Does This Compare With Biochemical Assays?
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In this study monoclonal antibodies to oestrogen receptors in the ER-ICA kit (Abbott) and to progesterone receptors (Biogenex) were used to determine the presence of those receptors in fine needle aspirates and cryostat sections. The degree of positivity is semi-quantitated and the results compared to biochemical assays (Dextran-Coated Charcoal Method) performed on the same specimens. Out of 14 cases that were positive on the biochemical assay, 11 (77%) were positive on ER-ICA performed on the FNA material, and there was a 100% agreement on the cryostat sections (11/11). PR-ICA on the cytospin smears and cryostat sections agreed in 63% and 90% respectively.
CitationEast Afr Med J. 1993 May;70(5):280-3.
Department of Pathology