dc.contributor.author | Mbugua, Njogu Peter | |
dc.date.accessioned | 2013-07-22T13:43:37Z | |
dc.date.available | 2013-07-22T13:43:37Z | |
dc.date.issued | 2012 | |
dc.identifier.citation | Degree of Doctor in Philosophy | en |
dc.identifier.uri | http://erepository.uonbi.ac.ke:8080/xmlui/handle/11295/49764 | |
dc.description.abstract | Alpha-hydroxy-(3-amino acids, isoserines, are important members of the (3-amino acids family because many of them act as potent enzyme inhibitors and as crucial building blocks for compounds of biological and medicinal importance. One such privileged amino acid· is {2R,3S}N-benzoyl-3-phenylisoserine, one of the two main structural motifs in the anticancer drug paclitaxel (Taxol®). This amino acid has been shown to play an essential role in the antimicrotubular activity of paclitaxel, a prototypical taxane. Taxanes are clinically used as antineoplastics. Previous independent research studies revealed that they also possess strong antimalarial efficacy. Structure activity relationship studies show that modifications of the {2R,3S}N-benzoyl-3~phenylisoserine moiety results in improvement of both the antineoplastic and antiplasmodial activities of taxanes. | en |
dc.language.iso | en | en |
dc.title | Molecular hybrids of (2R, 3S)-N-benzoyl-3-phenylisoserine with antimalarial scaffolds design, synthesis and biological evaluation for antitumoural and antiplasmodial activity | en |
dc.type | Thesis | en |
dc.description.department | a
Department of Psychiatry, University of Nairobi, ; bDepartment of Mental Health, School of Medicine,
Moi University, Eldoret, Kenya | |
local.publisher | Department of Pharmaceutical Chemistry | en |