dc.contributor.author | Yu VY, | |
dc.contributor.author | Baker, LS | |
dc.contributor.author | Tong, S, | |
dc.contributor.author | Murila, F, | |
dc.contributor.author | Robertson, MC, | |
dc.contributor.author | Wallace EM. | |
dc.date.accessioned | 2013-07-30T06:26:43Z | |
dc.date.available | 2013-07-30T06:26:43Z | |
dc.date.issued | 2009 | |
dc.identifier.citation | Robertson MC, Murila F, Tong S, Baker LS, Yu VY, Wallace EM. 2009. Predicting perinatal outcome through changes in umbilical artery Doppler studies after antenatal corticosteroids in the growth-restricted fetus.. Obstet Gynecol. 2009 Mar;113(3):636-40. doi: 10.1097/AOG.0b013e318197bf4d.. | en |
dc.identifier.uri | http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/52189 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/pubmed/19300328 | |
dc.description.abstract | OBJECTIVE:
To investigate whether persistently absent umbilical artery end-diastolic flow in the intrauterine growth-restricted fetus after betamethasone administration is associated with altered perinatal outcomes.
METHODS:
This is a retrospective cohort study of 92 pregnancies complicated by intrauterine growth restriction (IUGR) and absent end-diastolic flow in which antenatal betamethasone was given. Predefined maternal outcomes (maternal age, gestational age at diagnosis of absent end-diastolic flow, gestational age at delivery, preexisting medical conditions) and neonatal outcomes (including birth weight; perinatal mortality; duration of neonatal intensive care unit admission; requirement for intubation, assisted ventilation, inotropic support; duration of supplemental oxygen, assisted ventilation; respiratory distress syndrome, necrotizing enterocolitis, intraventricular hemorrhage) were analyzed.
RESULTS:
Betamethasone administration was associated with a transient return of end-diastolic umbilical artery flow in 58 pregnancies (63%) and persistent absent end-diastolic flow in 34 (37%). Persistent absent end-diastolic flow was seen more frequently in women with prepregnancy medical disorders (59% compared with 24%, P<.001). Neonates from the persistent absent end-diastolic flow subgroup were more likely to require assisted ventilation (93.1% compared with 73.5%, P=.03) and to have longer durations of assisted ventilation (median time 30 days compared with 4 days, P=.03) and supplemental oxygen (median time 45 days compared with 4 days, P=.04).
CONCLUSION:
Betamethasone administration is associated with a transient return of end-diastolic flow in two thirds of pregnancies complicated by IUGR and umbilical artery absent end-diastolic flow. Persistent absent end-diastolic flow in the umbilical artery after betamethasone administration may identify a subgroup of fetuses with IUGR at further heightened perinatal risk that, as neonates, are more likely to require assisted ventilation and a longer duration of ventilation and supplemental oxygen. | |
dc.language.iso | en | en |
dc.title | Predicting perinatal outcome through changes in umbilical artery Doppler studies after antenatal corticosteroids in the growth-restricted fetus | en |
dc.type | Article | en |
local.publisher | Department of Paediatrics & Child Health, University o0f Nairobi | en |