Synthesis of Steroidal Indoxyl, and Derivatives from 3-ketosteroid

dc.contributor.author	Kamau, FN
dc.date.accessioned	2013-07-31T09:05:27Z
dc.date.available	2013-07-31T09:05:27Z
dc.date.issued	2005
dc.identifier.citation	The East and Central African Journal of Pharmaceutical Sciences Vol. 8 (3) 2005: pp. 43-44	en
dc.identifier.uri	http://www.ajol.info/index.php/ecajps/article/view/9725
dc.identifier.uri	http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/52923
dc.description.abstract	5&alpha-Androstan-17&beta-ol-3-one condenses with 2-nitrobenzaldehyde in alkaline conditions to give the steroidal indoxyl 17&beta-hydroxy-1-(3′-oxoindan-2′-yliden)-3-nor-1,2-secoandrostan-3-oic acid (I) which on refluxing with acetic anhydride affords the lactam 17&beta-acetoxy-3′-aza-4a-homoandrost-1-eno-(3,2-a)-indan-3′,4-dione (II). Reduction of I with sodium borohydride gives the indole 17&beta-hydroxy-1-(indol-2′-yl)-3-nor-1, 2-secoandrostan-3-oic acid (III). The results of this synthesis suggest that 3-ketosteroids saturated in ring A react in a similar manner to 17-ketosteroids, with 2-nitrobenzaldehyde.	en
dc.language.iso	en	en
dc.publisher	University of Nairobi	en
dc.subject	Synthesis, Steroidal Indoxyl, derivatives.	en
dc.title	Synthesis of Steroidal Indoxyl, and Derivatives from 3-ketosteroid	en
dc.type	Article	en
local.publisher	Department of Pharmaceutical Chemistry, School of Pharmacy, College of Health Sciences, University of Nairobi.	en