Anti-Inflammatory and Anti-Diarrhoeal Activities of a Steroidal Indoxyl
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Date
2003Author
Kamau, FN
Kibwage, IO
Guantai, AN
Muriuki, G
Munenge, R
Type
ArticleLanguage
enMetadata
Show full item recordAbstract
The anti-inflammatory and antidiarrhoeal activities of 3β-Hydroxy-16, 17-seco-16-nor-5-androsten-15-(2-indoxyliden)-17-oic acid (I) are reported. After intraperitoneal administration, compound (I) gave an ED50 of 9.5 mg/kg using the carrageenan induced rat paw oedema anti-inflammatory assay method. Indomethacin had an ED50 of 5.8 mg/kg in this assay. Compound (I) and indomethacin caused comparable and dose-dependent varying degrees of delay in diarrhoea and also significantly reduced net colonic water flux into the colon of rats induced by castor oil.
Key words: Steroidal Indoxyl, Anti-Inflammatory, Antidiarrhoeal.
URI
http://www.ajol.info/index.php/ecajps/article/view/9695http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/52927
Citation
East and Central African Journal of Pharmaceutical Sciences Vol.6(2) 2003: 26-29Publisher
University of Nairobi Department of Pharmaceutical Chemistry, School of Pharmacy, College of Health Sciences, University of Nairobi.
Collections
- Faculty of Health Sciences (FHS) [10387]