dc.contributor.author | Khodarev, N | |
dc.contributor.author | Ahmad, R | |
dc.contributor.author | Rajabi, H | |
dc.contributor.author | Pitroda, S | |
dc.contributor.author | Kufe, T | |
dc.contributor.author | McClary, C | |
dc.contributor.author | Joshi, MD | |
dc.contributor.author | MacDermed, D | |
dc.contributor.author | Weichselbaum, R | |
dc.contributor.author | Kufe, D | |
dc.date.accessioned | 2013-07-31T11:23:07Z | |
dc.date.available | 2013-07-31T11:23:07Z | |
dc.date.issued | 2009 | |
dc.identifier.citation | Oncogene. 2010 Feb 11;29(6):920-9. doi: 10.1038/onc.2009.391. Epub 2009 Nov 16. | en |
dc.identifier.uri | www.ncbi.nlm.nih.gov/pubmed/19915608 | |
dc.identifier.uri | http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/53022 | |
dc.description.abstract | Signal transducer and activator of transcription 1 (STAT1) is activated in the inflammatory response to interferons. The MUC1 oncoprotein is overexpressed in human breast cancers. Analysis of genes differentially expressed in MUC1-transformed cells has identified a network linking MUC1 and STAT1 that is associated with cellular growth and inflammation. The results further show that the MUC1-C subunit associates with STAT1 in cells and the MUC1-C cytoplasmic domain binds directly to the STAT1 DNA-binding domain. The interaction between MUC1-C and STAT1 is inducible by IFNgamma in non-malignant epithelial cells and constitutive in breast cancer cells. Moreover, the MUC1-STAT1 interaction contributes to the activation of STAT1 target genes, including MUC1 itself. Analysis of two independent databases showed that MUC1 and STAT1 are coexpressed in about 15% of primary human breast tumors. Coexpression of MUC1 and the STAT1 pathway was found to be significantly associated with decreased recurrence-free and overall survival. These findings indicate that (i) MUC1 and STAT1 function in an auto-inductive loop, and (ii) activation of both MUC1 and the STAT1 pathway in breast tumors confers a poor prognosis for patients. | en |
dc.language.iso | en | en |
dc.publisher | University of Nairobi | en |
dc.title | Cooperativity of the MUC1 oncoprotein and STAT1 pathway in poor prognosis human breast cancer. | en |
dc.type | Article | en |
local.publisher | Faculty of medicine | en |