Synthesis of alpha-amyrin derivatives and their in vivo antihyperglycemic activity.
dc.contributor.author | Narender, T | |
dc.contributor.author | Khaliq, T | |
dc.contributor.author | Singh, AB | |
dc.contributor.author | Joshi, MD | |
dc.contributor.author | Mishra, P | |
dc.contributor.author | Chaturvedi, JP | |
dc.contributor.author | Srivastava, AK | |
dc.contributor.author | Maurya, R | |
dc.contributor.author | Agarwal, SC | |
dc.date.accessioned | 2013-07-31T13:19:29Z | |
dc.date.available | 2013-07-31T13:19:29Z | |
dc.date.issued | 2008 | |
dc.identifier.citation | Eur J Med Chem. 2009 Mar;44(3):1215-22. doi: 10.1016/j.ejmech.2008.09.011. Epub 2008 Sep 19. | en |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/pubmed/18947904 | |
dc.identifier.uri | http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/53043 | |
dc.description.abstract | Ficus racemosa belongs to the family of Moraceae and is commonly known as 'Gular' in north India. Bio-activity guided isolation work on the fruits of F. racemosa resulted in the identification of antidiabetic active principle, alpha-amyrin acetate 7. Compound 7 lowered the blood glucose levels by 18.4 and 17.0% at 5 and 24 h, respectively, in sucrose challenged streptozotocin induced diabetic rat (STZ-S) model at the dose of 100 mg/kg body weight. Fifteen novel derivatives viz, 9-21, 24, 25 of alpha-amyrin 8 were prepared and their antihyperglycemic activity profile was assessed. The p-chlorobenzoic acid derivative 9 and nicotinic acid derivative 14 showed potent antihyperglycemic activity at 100 mg/kg body weight. | en |
dc.language.iso | en | en |
dc.publisher | University of Nairobi | en |
dc.title | Synthesis of alpha-amyrin derivatives and their in vivo antihyperglycemic activity. | en |
dc.type | Article | en |
local.publisher | Faculty of medicine | en |
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