| dc.contributor.author | Kariuki, S | |
| dc.contributor.author | Corkill, JE | |
| dc.contributor.author | Revathi, G | |
| dc.contributor.author | Musoke, R | |
| dc.contributor.author | Hart, CA | |
| dc.date.accessioned | 2013-08-02T12:34:24Z | |
| dc.date.available | 2013-08-02T12:34:24Z | |
| dc.date.issued | 2001 | |
| dc.identifier.citation | Kariuki, S., Corkill, J. E., Revathi, G., Musoke, R., & Hart, C. A. (2001). Molecular characterization of a novel plasmid-encoded cefotaximase (CTX-M-12) found in clinical Klebsiella pneumoniae isolates from Kenya. Antimicrobial agents and chemotherapy, 45(7), 2141-2143. | en |
| dc.identifier.uri | http://aac.asm.org/content/45/7/2141.full.pdf+html | |
| dc.identifier.uri | http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/54061 | |
| dc.description.abstract | Nine Klebsiella pneumoniae isolates, six from blood and three from cerebrospinal fluid of newborn babies at
Kenyatta National Hospital, Nairobi, Kenya, were analyzed for the mechanism of cephalosporin resistance. By
using pulsed-field gel electrophoresis of XbaI-digested chromosomal DNA, all the nine isolates were found to
be clonal. PCR and direct sequencing revealed a novel extended-spectrum b-lactamase, which we designated
CTX-M-12. It has a more potent hydrolytic activity against cefotaxime than against ceftazidime and a pI of 9.0
and is encoded on a large self-transferable ca. 160-kbp plasmid | en |
| dc.language.iso | en | en |
| dc.publisher | University of Nairobi, | en |
| dc.title | Molecular Characterization of a Novel Plasmid-Encoded Cefotaximase (CTX-M-12) Found in Clinical Klebsiella pneumoniae Isolates from Kenya | en |
| dc.type | Article | en |
| local.publisher | Department of Paediatric & Microbiology | en |
