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dc.contributor.authorAwah, FM
dc.contributor.authorUzoegwu, PN
dc.contributor.authorIfeonu, P
dc.contributor.authorOyugi, JO
dc.contributor.authorRutherford, J
dc.contributor.authorYao, X
dc.contributor.authorEze, MO
dc.date.accessioned2013-08-14T06:03:44Z
dc.date.available2013-08-14T06:03:44Z
dc.date.issued2012
dc.identifier.citationAwah, F. M., Uzoegwu, P. N., Ifeonu, P., Oyugi, J. O., Rutherford, J., Yao, X., ... & Eze, M. O. (2012). Free radical scavenging activity, phenolic contents and cytotoxicity of selected Nigerian medicinal plants. Food Chemistry, 131(4), 1279-1286.en
dc.identifier.urihttp://www.sciencedirect.com/science/article/pii/S0308814611013951
dc.identifier.urihttp://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/56166
dc.description.abstractWe investigated the antioxidant ability, phenolic contents and cytotoxic effects of seven widely edible Nigerian medicinal plants, as a means of validating their ethnomedicinal use. Standard antioxidant assays assessed the capability of the extracts in scavenging 2,2-diphenyl-1-picrylhydrazyl (DPPH), hydroxyl (radical dotOH), and superoxide anion View the MathML source(O2-) radicals, as well as in inhibiting lipid peroxidation. The extracts possessed significant antioxidant activity compared to standards and the 7-amino actinomycin and WST-1 cytotoxicity assays proved that they were non-toxic to human peripheral blood mononuclear cells, and the A2.01 cell line. Landolphia owariensis and Irvingia gabonensis had the most antioxidant activity in the DPPH assay, compared to ascorbic acid. They also significantly inhibited lipid peroxidation. I. gabonensis and Nauclea latifolia powerfully quenched the radical dotOH radical compared to α-tocopherol. The extracts’ antioxidant activity and lipid peroxidation inhibitory potencies correlated with their phenolic and flavonoid contents. Thus, the antioxidant activities could be factors contributing substantially to their traditional medicinal use.en
dc.language.isoenen
dc.publisherUniversity of Nairobi,en
dc.subjectNigerian medicinal plantsen
dc.subjectAntioxidant activityen
dc.subjectPhenolic contentsen
dc.subjectCytotoxicityen
dc.titleFree radical scavenging activity, phenolic contents and cytotoxicity of selected Nigerian medicinal plantsen
dc.typeArticleen
local.publisherDepartment of Medical Microbiology-en


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